Nucleus Subcoeruleus

The abstract from an article, "A Quantitative Study of the Pigmented Neurons in the Nuclei Locus Coeruleus and Subcoeruleus in Man as Related to Aging" in the Journal of Neuropathology & Experimental Neurology states the following:

"The nuclei of the locus coeruleus and subcoeruleus were examined in human brains from individuals of 14 to 87 years. Serial counts were performed on every tenth Nissl stained paraffin section of melanin containing cells within the entire length of these nuclei. After 63 years, the neuronal population in these nuclei decreased 40%. This significant decrease in cell number is the first reported for a brain stem structure. In view of the relation of these noradrenaline containing cells to the catecholaminergic system and the widespread projections between these nuclei and other central nervous system structures, this decrease may be a factor in alteration of some central nervous system activities with increasing age."

This summary indicates that after the age of 63, a decrease in melanin occurs in specific loci of the amenta changing or perhaps debilitating the central nervous system (CNS) and leading to aging.

The inverse logic therefore holds that with increased neural activities leading to re-pigmentation and increased melanin to the nucleus subcoeruleus and the locus coeruleus, aging could be reversed or mitigated.